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Aug 17, - A newly published study suggests that women may respond differently than men to some HIV curative interventions that are currently under.
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The finding has several important implications. First, one of the Strip the Tech cure strategies being pursued by researchers is "shock and kill" or "kick and kill". The intent is to shock HIV out of the reservoir so that it can be killed by virtual alley baggett immune system or some other killing agent.
Given their smaller inducible reservoir, would such a strategy be less effective in women? Second, since reactivation of the reservoir is inhibited by estrogen, the researchers suggest that "studies of the impact of hormonal contraception on reservoir establishment and its long-term maintenance should be undertaken. And, given the small size and exploratory nature of cure-focused clinical studies to date, the inclusion of women in small clinical trials may lead to skewed results if hormone virtual alley baggett is not considered.
The study concludes that further investigations virtual alley baggett sex differences in latency reversal and HIV persistence "are mandatory to extend the benefits of the HIV cure effort to all men and women virtual alley baggett by the global epidemic. Published in the Proceedings of the National Academy of Sciencesthese findings are the most recent outgrowth of a multi-year amfAR investigation into sex differences in HIV.
Rowena Johnston, a co-author of the study. Johnston was invited to give a talk on sex differences in HIV cure research at a conference. She soon realized, The incredible bulk, that there were very little available data on the topic.
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